Angelica is a perennial herb belonging to the Umbelliferae, which was first recorded in the "Shen Nong's Materia Medica". Angelica sinensis is sweet, warm in nature, and enters the heart, liver and spleen meridians, and contains flavonoids, coumarin polysaccharides, organic acids and other substances. Angelica sinensis is widely used in clinical practice. It is known as "Ten Fangs and Nine Returns" and "King of Medicines". Traditional Chinese medicine believes that "hair is blood, and those with dry hair are blood deficiency." Traditional Chinese medicine treats hair loss from nourishing blood and activating blood. In the anti-hair loss prescription, most of the medicinal materials that nourish blood and nourish qi are mainly used, such as angelica, ginseng, and astragalus.

The researchers investigated the effect of different concentrations of Angelica polysaccharides on the growth of human scalp hair, and the results showed that low doses of Angelica polysaccharides could promote the growth of human scalp hair follicles cultured in vitro. To observe the clinical efficacy of compound ginger juice angelica lotion in the treatment of seborrheic alopecia, compared with oral finasteride tablets and topical 2% minoxidil solution, it is found that ginger juice angelica lotion has the advantages of safety, effectiveness and no toxic and side effects . Kim et al. studied the effect of Angelica on hair growth and the mechanism of keratinocyte apoptosis regression during degenerative period in mice, and found that Angelica extract can reduce the expression of caspase-3 and increase BcI-2 by reducing the expression of cleavage caspase-3. /Bax ratio to regulate the apoptosis of hair keratinocytes, so as to achieve the effect of promoting hair regeneration. Tae-Kyeong et al. found that the Korean angelica extract may promote hair growth by regulating inflammatory factors, such as significantly down-regulating inflammatory factors TNF-a and IL-1β. Hair is produced from hair follicles, which are complex appendages of the skin. Hair is highly sensitive to many growth factors, cytokines, hormones, neuropeptides, drugs and other internal and external factors during the growth process, and is regulated by multiple signaling pathways. Based on the current literature reports, Angelica may promote hair growth through a variety of ways.

Through the inhibition model of type I 5a-reductase, the effect of Angelica sinensis extract on hair growth rate-limiting enzyme was investigated. The animal experiments on C57BL/6 mice showed that the extract of Angelica sinensis has the effect of promoting the hair growth of C57BL/6 mice; the efficacy of the scalp care essence prepared with the extract of Angelica sinensis was evaluated by the population, and the results showed that the extract of Angelica sinensis could improve the hair loss.