The clinical application of medlar in modern medicine in eye diseases, one is to inherit the traditional application of dried fruit medlar, and the compound use of single-flavored medlar or medlar as the main medicine; the other is the use of medlar extract, especially Lycium barbarum polysaccharide, Research and application of carotenoids in eye diseases.

1. Clinical application of dried wolfberry fruit

The direct clinical application of dried fruit Lycium barbarum in eye diseases is currently the most common form, either as a single drug or a compound recipe with Lycium barbarum as the main drug. Current clinical research shows that wolfberry can be used for the treatment of diabetic retinopathy, myopia, retinitis pigmentosa, senile cataract, age-related macular degeneration, dry eye, and other eye diseases. Through a 12-month double-blind controlled clinical study, Chan et al found that supplementation of medlar has a protective effect on vision and macular structure in patients with retinitis pigmentosa, and this neuroprotective effect of medlar can delay or minimize retinitis pigmentosa Cone degeneration in . Luodan treated liver and kidney yin deficiency type retinitis pigmentosa with medlar, Rehmannia glutinosa and other nourishing liver and kidney drugs, and the clinical effect was satisfactory. A series of clinical studies have found that the compound Ziyin Mingmu Pills, which mainly nourish the liver and kidneys, such as wolfberry fruit, Rehmannia glutinosa, and dodder seed, can be used to treat senile cataracts, wet age-related macular degeneration, yin deficiency type dry eye, liver and kidney disease. The clinical efficacy of kidney-yin deficiency type retinitis pigmentosa and age-related macular degeneration is remarkable.

2. Research and application of Lycium barbarum extract

Lycium barbarum is rich in wolfberry polysaccharides, carotenoids, riboflavin, vitamin C, taurine, amino acids and various trace elements. The study found that the main effective components of Lycium barbarum for improving eyesight are Lycium barbarum polysaccharides and carotenoids. Lycium barbarum polysaccharide is one of the main bioactive components of Lycium barbarum, which consists of 6 different monosaccharides, including arabinose, glucose, galactose, mannose, xylose, and rhamnose. Lycium barbarum polysaccharide has antioxidant and optic nerve protection effects.

A 30-day randomized double-blind controlled clinical trial showed that Lycium barbarum polysaccharide can significantly increase serum superoxide dismutase and glutathione peroxidase levels in healthy Chinese adults, and significantly reduce serum malondialdehyde levels. Level. At present, a large number of animal experiments and in vitro cell experiments have shown that Lycium barbarum polysaccharide can be used to treat a variety of fundus diseases, among which the more in-depth research is glaucoma, retinitis pigmentosa and diabetic retinopathy. However, at present, there is no clinical trial on the direct use of Lycium barbarum polysaccharide in the treatment of glaucoma, retinitis pigmentosa, diabetic retinopathy and other eye diseases. At present, the research of Lycium barbarum polysaccharide in eye diseases is still in the laboratory research stage. With the research progress of the mechanism, absorption and metabolism of Lycium barbarum polysaccharides in eye diseases, the extensive clinical application of Lycium barbarum polysaccharides in eye diseases can be expected in the future.